![This study identified key differences in transendocytosis by CTLA-4 when activated by CD80 and CD86 ligands; whereby CD80 binding led to targeted ubiquitination and lysosomal degradation while CD86 binding led to enhanced This study identified key differences in transendocytosis by CTLA-4 when activated by CD80 and CD86 ligands; whereby CD80 binding led to targeted ubiquitination and lysosomal degradation while CD86 binding led to enhanced](https://www.cytoskeleton.com/media/Feb_14_CS_image_2.gif)
This study identified key differences in transendocytosis by CTLA-4 when activated by CD80 and CD86 ligands; whereby CD80 binding led to targeted ubiquitination and lysosomal degradation while CD86 binding led to enhanced
![3 CD80 and CD86 deliver bidirectional signaling for the activation of T... | Download Scientific Diagram 3 CD80 and CD86 deliver bidirectional signaling for the activation of T... | Download Scientific Diagram](https://www.researchgate.net/publication/274386360/figure/fig2/AS:978234644631553@1610240722589/CD80-and-CD86-deliver-bidirectional-signaling-for-the-activation-of-T-cell-and-APC.png)
3 CD80 and CD86 deliver bidirectional signaling for the activation of T... | Download Scientific Diagram
Binding of CD80/CD86 and cytotoxic T-lymphocyte-associated protein 4... | Download Scientific Diagram
![Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation | Nature Immunology Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation | Nature Immunology](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41590-022-01289-w/MediaObjects/41590_2022_1289_Fig3_HTML.png)
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation | Nature Immunology
![2 CD80/CD86 deliver bidirectional signaling for the activation of T... | Download Scientific Diagram 2 CD80/CD86 deliver bidirectional signaling for the activation of T... | Download Scientific Diagram](https://www.researchgate.net/publication/274386280/figure/fig2/AS:978234418151425@1610240668507/CD80-CD86-deliver-bidirectional-signaling-for-the-activation-of-T-cell-and-APC-Cognate.jpg)
2 CD80/CD86 deliver bidirectional signaling for the activation of T... | Download Scientific Diagram
![In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET | Molecular Imaging and Biology In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET | Molecular Imaging and Biology](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs11307-020-01543-3/MediaObjects/11307_2020_1543_Fig2_HTML.png)
In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET | Molecular Imaging and Biology
![CD28 is constitutively expressed on T cells and CD86 is expressed on... | Download Scientific Diagram CD28 is constitutively expressed on T cells and CD86 is expressed on... | Download Scientific Diagram](https://www.researchgate.net/publication/7904322/figure/fig3/AS:294410890825742@1447204434354/CD28-is-constitutively-expressed-on-T-cells-and-CD86-is-expressed-on-antigen-presenting.png)
CD28 is constitutively expressed on T cells and CD86 is expressed on... | Download Scientific Diagram
![Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells | PNAS Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells | PNAS](https://www.pnas.org/cms/10.1073/pnas.2023739118/asset/547ddeea-0f25-4733-845a-d904ec0ce15c/assets/images/large/pnas.2023739118fig01.jpg)
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells | PNAS
![Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex® - Heninger - 2014 - Immunity, Inflammation and Disease - Wiley Online Library Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex® - Heninger - 2014 - Immunity, Inflammation and Disease - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/40535b99-fbe7-4df2-93fd-7538fced1204/iid334-fig-0001-m.jpg)
Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex® - Heninger - 2014 - Immunity, Inflammation and Disease - Wiley Online Library
![Efficiency of T‐cell costimulation by CD80 and CD86 cross‐linking correlates with calcium entry - Thiel - 2010 - Immunology - Wiley Online Library Efficiency of T‐cell costimulation by CD80 and CD86 cross‐linking correlates with calcium entry - Thiel - 2010 - Immunology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/9f6712f7-37f5-4f3a-b3c9-a8bce158c26f/imm_3155_f9.gif)
Efficiency of T‐cell costimulation by CD80 and CD86 cross‐linking correlates with calcium entry - Thiel - 2010 - Immunology - Wiley Online Library
![Figure 8 from Dominant Role of CD80–CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LATY136F CD4+ T Cells | Semantic Scholar Figure 8 from Dominant Role of CD80–CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LATY136F CD4+ T Cells | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/1228111f410b4705b3a54a3b7690184a13b6b7f3/10-Figure8-1.png)
Figure 8 from Dominant Role of CD80–CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LATY136F CD4+ T Cells | Semantic Scholar
![Frontiers | The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis Frontiers | The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis](https://www.frontiersin.org/files/Articles/598076/fmed-08-598076-HTML/image_m/fmed-08-598076-g001.jpg)